Rosetta Omics

The protein histidine phosphatase LHPP is a tumour suppressor.

Hindupur SK, Colombi M, Fuhs SR, Matter MS, Guri Y, Adam K, Cornu M, Piscuoglio S, Ng CKY, Betz C, Liko D, Quagliata L, Moes S, Jenoe P, Terracciano LM, Heim MH, Hunter T, Hall MN. Nature. 2018 Mar 29;555(7698):678-682. doi: 10.1038/nature26140. Epub 2018 Mar 21. PMID: 29562234 Free PMC article.

NME/NM23/NDPK and Histidine Phosphorylation.

Adam K, Ning J, Reina J, Hunter T. Int J Mol Sci. 2020 Aug 14;21(16):5848. doi: 10.3390/ijms21165848. PMID: 32823988 Free PMC article. Review.

The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis.

Adam K, Lesperance J, Hunter T, Zage PE. Int J Mol Sci. 2020 May 7;21(9):3319. doi: 10.3390/ijms21093319. PMID: 32392889 Free PMC article.

Subcellular Localization of Histidine Phosphorylated Proteins Through Indirect Immunofluorescence.

Adam K, Hunter T. Methods Mol Biol. 2020;2077:209-224. doi: 10.1007/978-1-4939-9884-5_14. PMID: 31707661 Free PMC article.

Empirical Evidence of Cellular Histidine Phosphorylation by Immunoblotting Using pHis mAbs.

Kalagiri R, Adam K, Hunter T. Methods Mol Biol. 2020;2077:181-191. doi: 10.1007/978-1-4939-9884-5_12. PMID: 31707659 Free PMC article.

A non-acidic method using hydroxyapatite and phosphohistidine monoclonal antibodies allows enrichment of phosphopeptides containing non-conventional phosphorylations for mass spectrometry analysis

K. Adam, S. Fuhs, J. Meisenhelder, A. Aslanian, J. Diedrich, J. Moresco, J. La Clair, J.R. Yates III, T. Hunter

bioRxiv 691352; doi: https://doi.org/10.1101/691352

A PIM-CHK1 signaling pathway regulates PLK1 phosphorylation and function during mitosis.

Adam K, Cartel M, Lambert M, David L, Yuan L, Besson A, Mayeux P, Manenti S, Didier C. J Cell Sci. 2018 Aug 10;131(15):jcs213116. doi: 10.1242/jcs.213116. PMID: 29976560

Histidine kinases and the missing phosphoproteome from prokaryotes to eukaryotes.

Adam K, Hunter T. Lab Invest. 2018 Feb;98(2):233-247. doi: 10.1038/labinvest.2017.118. Epub 2017 Oct 23. PMID: 29058706 Free PMC article. Review.

Control of Pim2 kinase stability and expression in transformed human haematopoietic cells.

Adam K, Lambert M, Lestang E, Champenois G, Dusanter-Fourt I, Tamburini J, Bouscary D, Lacombe C, Zermati Y, Mayeux P. Biosci Rep. 2015 Oct 23;35(6):e00274. doi: 10.1042/BSR20150217. PMID: 26500282 Free PMC article.

Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia.

Green AS, Maciel TT, Hospital MA, Yin C, Mazed F, Townsend EC, Pilorge S, Lambert M, Paubelle E, Jacquel A, Zylbersztejn F, Decroocq J, Poulain L, Sujobert P, Jacque N, Adam K, So JC, Kosmider O, Auberger P, Hermine O, Weinstock DM, Lacombe C, Mayeux P, Vanasse GJ, Leung AY, Moura IC, Bouscary D, Tamburini J. Sci Adv. 2015 Sep 18;1(8):e1500221. doi: 10.1126/sciadv.1500221. eCollection 2015 Sep. PMID: 26601252 Free PMC article.

Tyrosine kinase inhibitors induce down-regulation of c-Kit by targeting the ATP pocket.

D’allard D, Gay J, Descarpentries C, Frisan E, Adam K, Verdier F, Floquet C, Dubreuil P, Lacombe C, Fontenay M, Mayeux P, Kosmider O. PLoS One. 2013 Apr 23;8(4):e60961. doi: 10.1371/journal.pone.0060961. Print 2013. PMID: 23637779 Free PMC article.

Mezger STP, Mingels AMA, Bekers O, Heeren RMA, Cillero-Pastor B. Anal Chem. 2021 Feb 2;93(4):2527-2533. doi: 10.1021/acs.analchem.0c04572. Epub 2021 Jan 7. PMID: 33412004 Free PMC article.

Specific Lipid and Metabolic Profiles of R-CHOP-Resistant Diffuse Large B-Cell Lymphoma Elucidated by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and in Vivo Imaging.

Barré FPY, Claes BSR, Dewez F, Peutz-Kootstra C, Munch-Petersen HF, Grønbæk K, Lund AH, Heeren RMA, Côme C, Cillero-Pastor B. Anal Chem. 2018 Dec 18;90(24):14198-14206. doi: 10.1021/acs.analchem.8b02910. Epub 2018 Dec 4. PMID: 30422637 Free PMC article.

Protein Alterations in Cardiac Ischemia/Reperfusion Revealed by Spatial-Omics.

Mezger STP, Mingels AMA, Soulié M, Peutz-Kootstra CJ, Bekers O, Mulder P, Heeren RMA, Cillero-Pastor B. Int J Mol Sci. 2022 Nov 10;23(22):13847. doi: 10.3390/ijms232213847. PMID: 36430335 Free PMC article.

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) reveals potential lipid markers between infrapatellar fat pad biopsies of osteoarthritis and cartilage defect patients.

Haartmans MJJ, Claes BSR, Eijkel GB, Emanuel KS, Tuijthof GJM, Heeren RMA, Emans PJ, Cillero-Pastor B. Anal Bioanal Chem. 2023 Oct;415(24):5997-6007. doi: 10.1007/s00216-023-04871-9. Epub 2023 Jul 28. PMID: 37505238 Free PMC article.

https://www.e-cancer.fr/Professionnels-de-sante/Les-chiffres-du-cancer-en-France/Epidemiologie-des-cancers/Les-cancers-les-plus-frequents/Cancer-colorectal

https://www.e-cancer.fr/Comprendre-prevenir-depister/Se-faire-depister/Depistage-du-cancer-colorectal

https://www.who.int/news-room/fact-sheets/detail/colorectal-cancer

https://pubmed.ncbi.nlm.nih.gov/?term=Colorectal+cancer&sort=date

https://clinicaltrials.gov/search?cond=Colorectal%20Cancer

Fritz, J., Lefebvre, O., Fernandez, A., Schmidt, J., & Bagnard, D. (2020a). Prediction of Drug Efficacy in Colon Cancer Preclinical Models Using a Novel Ranking Method of Gene Expression. Cancers, 12(1), 149. https://doi.org/10.3390/cancers12010149 Published 08/01/2020

Verlingue, L., Morel, D., Schaeffer, M., Tanguy, L., Schmidt, J., Bernhard, J., Loubaton, B., & Bagnard, D. (2021). Denoised VEGFR2 expression relates to sunitinib efficacy in advanced clear cell renal cell carcinoma. Biomed J Sci & Tech Res, doi: 10.26717/bjstr.2022.40.006529. Published 11/01/2022